Breaks the flea life cycle. Four month supply. Flea eggs. Fleas ticks. Repels biting flies. Mosquitoes Lice. Repels & kills fleas, flea eggs, ticks and mosquitoes. Repels biting flies and kills lice. Waterproof. Contains Imidacloprid, Permithrin & Pyriproxyfen, the active ingredients found in K9 Advantix II for dogs (This product is not manufactured or distributed by Bayer, the maker of K9 Advantix II. K9 Advantix II is a registered trademark of Bayer.) Monthly Topical Treatment of Fleas, Ticks, Mosquitoes, Biting Flies and Lice. TevraPet Activate II Large Dog rapidly kills fleas and may reduce the incidence of flea allergy dermatitis (FAD), a hypersensitivity skin disorder which may be induced by the feeding activity of fleas. TevraPet Activate II Large Dog kills existing fleas on dogs within 12 hours. Any other fleas that jump on the dog are killed within 2 hours. Protection against further flea infestation lasts at least four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climate. Flea larvae in the dog's surroundings are killed following contact with a Tevra Pet Activate II Large Dog treated dog. TevraPet Activate II Large Dog is waterproof and will remain effective even after a shampoo treatment, after swimming, or after exposure to rain or sunlight. For best results, use monthly treatments for flea and tick control. Hot Line Number: Have the product container or label with you when calling a poison control center or doctor, or going for treatment. For more information on this pesticide product (including health concerns, medical emergencies or pesticide incidents), you may call 1-800-775-9416. If you have questions or comments about this product, please write: Tevra Brands Pet Owner Response, 9100 F Street, Suite 200, Omaha, NE 68127. In Case of Emegency, call: 1-800-775-9416. Non-Emergency call: 1-844-276-3290.